商品编号


JP10379



品牌


IBL



公司


IBL,inc



公司分类


Neurodegeneration & Neurotransmitters


商品信息

Quantity / Tests
50 ?g
Species / Antigen
Synthetic peptide of E22P- Amyloidβ10-35 part
Host
Mouse
Subclass / Clone
IgG1/11A1
Type
Monoclonal
Purification
Protein A
Label
No
Regulatory Status:
For research use only


Details for:


?
Anti-human Amyloid-beta E22P (11A1) Mouse IgG

Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. Aggregation of the amyloid β-protein, especially the Aβ42 isoform, plays a critical role in the pathogenesis of AD. Shirasawa and Irie et. al have proposed a toxic conformer with a turn at positions 22 and 23, as well as a nontoxic conformer with a turn at positions 25 and 26, in Aβ42 aggregates from systematic proline scanning and solid-state NMR studies. This monoclonal antibody named 11A1 was developed for toxic Aβ42, using E22P-Aβ10-35, a minimum moiety for neurotoxicity containing the turn at positions 22 and 23, for the generation. Immunohistochemical studies showed that not only extracellular but intracellular amyloid was stained in human AD brains, which suggest that 11A1 could detect toxic oligomers of Aβ with the turn at positions 22 and 23.

For concrete data please consult the Instruction for Use in the download box on the right side.