商品编号


JP28133



品牌


IBL



公司


IBL,inc



公司分类




商品信息

Quantity / Tests
100 ?g
Species / Antigen
human
Host
rabbit
Subclass / Clone
IgG
Type
Polyclonal
Purification
with Antigen Peptide
Label
No
Regulatory Status:
For research use only


Details for:


?
Anti-Human APP770 (351) Rabbit IgG

This antibody has been raised against a synthetic peptide being part of human APP770.

Alzheimer's disease (AD) is a typical senile dementia and it is believed that accumulation of Amyloidβ (Aβ) in the brain parenchyma is a major cause of the disease. Meanwhile, accumulation of Aβ has also been observed on cerebrovascular walls of nearly 90% of all individuals suffering from AD. Aβ is known to be produced from Amyloidβ Precursor Protein (APP) by cleavage with two types of proteases (β- and γ- secretase) and Aβ molecules, which accumulate in brain parenchyma are mainly produced from APP expressed in neurons, APP695. In contrast to this, another different APP, APP770, was found to be expressed in cerebrovascular endothelial cells, and it has recently been reported that the Aβ produced from APP770 can accumulate on cerebrovascular walls.

Distributed by
IBL
International

For concrete data please consult the Instruction for Use in the download box on the right side.