商品编号


30135335



品牌


IBL



公司


IBL,inc



公司分类


Immunology / Cytokines


商品信息

Quantity / Tests
50 ?g
Species / Antigen
Synthetic peptide of human Amyloid-beta(38-42) (GVVIA)
Host
Mouse
Subclass / Clone
IgG2b
Type
Monoclonal
Purification
Protein A
Label
No
Regulatory Status:
For research use only


Details for:


?
Anti-Human Amyloid-beta (38-42) (44A3) Mouse IgG

"Original article #11115
Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid (Aβ) peptide, a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by β-secretase and γ-secretase. Increased release of Aβ42 or Aβ43, both of which exibit a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations, ApoE alleles or may involve other undiscovered factors. Many researchers theorize that it is this increased release of Aβ42/Aβ43 which leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals."

For concrete data please consult the Instruction for Use in the download box on the right side.