商品编号


JP10381



品牌


IBL



公司


IBL,inc



公司分类


Immunology / Cytokines


商品信息

Quantity / Tests
100 ?g
Species / Antigen
Recombinant protein of C-terminal portion of human CD109
Host
Mouse
Subclass / Clone
IgG1/11H3
Type
Monoclonal
Purification
Protein A
Label
No
Regulatory Status:
For research use only


Details for:


?
Anti-human CD109 (11H3) Mouse IgG

CD109 is a glycosyl-phosphatidyl-inositol (GPI) - anchored glycoprotein about 180 - 190 kDa size. It is shown that CD109 is expressed in vascular endothelial cells, some epithelial cells, activated T-cells and platelets, and subset of CD34+ megakaryocytic leukemia cells. The CD109 molecules are strongly expressed in KG1a cells, while CD34+CD109+ cells in fetal bone marrow include almost all myelocytic, erythroblastic and megakaryocytic precursor cells. For this reason, CD109 is considered to be a
Marker
of megakaryocytic hematopoiesis in early stage. And CD109 is considered different from existing activation
Marker
s of leukocytes and platelets, because of its structure and
SERO
logical features. By reports of Takahashi et al., CD109 is significantly over expressed in squamous cell carcinomas such as lung carcinoma, esophageal carcinoma and uterine cervical carcinoma. Thus, it is attracting attention for studying squamous cell carcinomas. Additionally, a recent study suggests that CD109 is involved in the regulation of transforming growth factor (TGF)-β signaling in some cancer cells and keratinocytes.

For concrete data please consult the Instruction for Use in the download box on the right side.