商品编号


JP28119



品牌


IBL



公司


IBL,inc



公司分类


Antibodies


商品信息

Quantity / Tests
100 ?g
Species / Antigen
Synthetic peptide of a part of Human CD109 (aa 461-478)
Host
Rabbit
Subclass / Clone
IgG
Type
Polyclonal
Purification
Affinity purified with antigen peptide
Label
No
Regulatory Status:
For research use only


Details for:


?
Anti-Human CD109 (461) Rabbit IgG

CD109 is a glycosyl-phosphatidyl-inositol (GPI) - anchored glycoprotein sized about 180 - 190 kDa. It has been shown that CD109 is expressed in vascular endothelial cells, some epithelial cells, activated T-cells and platelets, and a subset of CD34+ megakaryocytic leukemia cells. The CD109 molecules are strongly expressed in KG1a cells, while CD34+CD109+ cells in fetal bone marrow include almost all myelocytic, erythroblastic and megakaryocytic precursor cells. For this reason, CD109 is considered to be a
Marker
of megakaryocytic hematopoiesis in early stage. Fur
Thermo
re, CD109 is considered to be different from existing activation
Marker
s of leukocytes and platelets, because of its structure and
SERO
logical features.
By reports of Takahashi et al., CD109 is significantly over expressed in squamous cell carcinoma of lung tissue, esophageal tissue and uterine cervical tissue. Thus, it is attracting attention in studying squamous cell carcinoma. Additionally, a recent study suggests that CD109 is involved in the regulation of transforming growth factor (TGF)-β signaling in some cancer cells and keratinocytes.

Distributed by
IBL
International

For concrete data please consult the Instruction for Use in the download box on the right side.