商品编号


JP10047



品牌


IBL



公司


IBL,inc



公司分类


Neurodegeneration & Neurotransmitters


商品信息

Quantity / Tests
50 μg
Species / Antigen
Synthetic peptide of human Amyloid-beta (35-40) (MVGGVV)
Host
Mouse
Subclass / Clone
IgG1 / 1A10
Type
Monoclonal
Purification
Affinity purified with antigen peptide
Label
No
Regulatory Status:
For research use only


Details for:


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Anti-Human Amyloid-beta (35-40) (1A10) Mouse IgG MoAb

Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major component of these plaques is the beta amyloid peptide (Aβ), a 40 to 43 amino acid peptide cleaved from beta amyloid precursor protein by β-secretase and a putative γ-secretase. The ‘longer forms’ of Aβ peptide, Aβ42 or Aβ43, have a greater tendency to aggregate than Aβ40. Increased release of these peptides has been found to occur in individuals with genetic mutations of the ApoE alleles, and might also be caused by other still unknown mechanisms. Many researchers postulate that the increased release of Aβ42/Aβ43 may lead to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals.

Distributed by
IBL
International

For concrete data please consult the Instruction for Use in the download box on the right side.