商品编号


JP28073



品牌


IBL



公司


IBL,inc



公司分类


Antibodies


商品信息

Quantity / Tests
50 ?g
Species / Antigen
human
Host
rabbit
Subclass / Clone
IgG
Type
Polyclonal
Purification
with Antigen Peptide
Label
No
Regulatory Status:
For research use only


Details for:


?
Anti-Human C4.4A (301) Rabbit IgG

C4.4A is known to be present in the placenta, skin, esophagus and peripheral mononuclear cells in humans. It is a GPI (glycosylphosphatidylinositol) binding protein which has a similar structure to urokinase receptor (uPAR) and belongs to the Ly-6 family of proteins as does uPAR. While most of Ly-6 family proteins consist of single domains, uPAR is of three cysteine-rich domains. C4.4A is a membrane protein which binds to cell membrane at GPI binding site, and is consisting of two cysteine-rich domains and a cysteine lacking third domain.

C4.4A was first isolated from metastatic rat pancreatic cancer cell lines in 1989, and its human homolog was isolated in 2001. In human malignant tumors, it has been reported that C4.4A is expressed in malignant melanoma, urothelial, lung, esophageal and colon cancer. It is considered that C4.4A mediates invasion and metastasis of cancer cells by binding with laminin and degr
ADI
ng the extracellular matrix in the progress of cancer.

Therefore, immunological detection of C4.4A in cancerous tissue is expected to be an indicator of tumor metastasis.

Distributed by
IBL
International

For concrete data please consult the Instruction for Use in the download box on the right side.