商品编号


AG-40A-0081-C010



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Protein Jagged-1; hJ1; CD339; JAG1



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

Signal peptide and extracellular domain of human Jagged-1 (HJ1; CD339) (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG1.



Crossreactivity

Human



BIOLOG
ical Activity

Inhibits
ADI
pogen
esis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.



MW

~150kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.1eu>



Concentration

0.5mg/ml



Formulation

Liquid. 0.2μm-filtered solution in PBS.



Other Product Data

Uniprot link P78504: Jagged-1 [Precursor]



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (
in vitro
). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).


Product References

Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi): S.M. Thakurdas, et al.; Hepatology
63,
550 (2016)

Single factors alone can induce mesenchymal-like morphology, but not promote full EMT in breast cancer cell lines with different hormone statuses: M.K. Tveitaras, et al.; Exp. Cell Res.
359,
257 (2017)

Notch ligands regulate the muscle stem-like state?
ex vivo
?but are not sufficient for retaining regenerative capacity: H. Sakai, et al.; PLoS ONE
12,
e0177516 (2017)