商品编号


H6600



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

25 ?g

商品信息

USP
16 is an active deubiquitinating enzyme (DUB) encoded on chromosome 21, trisomy of which causes Down’s syndrome (DS).
USP
16 is a phosphoprotein, phosphorylation of
USP
16 controls its cellular localization, but no effect on its DUB activity.
USP
16 deubiquitinates histone 2A (H2A), through which
USP
16 might regulate gene expression and cell cycle progression. Increased
USP
16 protein levels in people with DS might contribute to the development of certain phenotypes of DS.

Additional Information






Product Name:

6xHis-
USP
16



Also Known As:

UBP-M; UBPM



Catalog No.:

H6600



Size:

25 ?g



Molecular Weight:

93.5 kDa



Species:

Human



Source:

Insect cell



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

>90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_006447.2



Image(s):

H6600 image

A. DUB activity assay: 15 nM
USP
16 + 500 nM Ub-Rhodamine 110. Rhodamine 110 fluorescence was monitored by a plate reader with excitation/emission wavelengths at 480/528 nm, respectively.




Shipping Method:

Dry ice shipping



References:

1. Joo H Y.,
et al
. (2007) Nature 449, 1068.
2. Adorno M.,
et al
. (2013) Nature 501, 380.




Details


USP
16 is an active deubiquitinating enzyme (DUB) encoded on chromosome 21, trisomy of which causes Down’s syndrome (DS).
USP
16 is a phosphoprotein, phosphorylation of
USP
16 controls its cellular localization, but no effect on its DUB activity.
USP
16 deubiquitinates histone 2A (H2A), through which
USP
16 might regulate gene expression and cell cycle progression. Increased
USP
16 protein levels in people with DS might contribute to the development of certain phenotypes of DS.