商品编号


F1425-5



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg

商品信息

CB-5083 is a potent ATPase activity inhibitor of p97. p97 (also called VCP) is an AAA-ATPase that plays an important role in various cellular functions including ER-associated degradation. CB-5803 induces significant unfolded protein response and apoptosis of various cancer cells. P97 is orally active and currently in clinical trials for relapsed multiple myeloma.

Additional Information






Product Name:

CB-5083



Also Known As:

CAS# 1542705-92-9



Catalog No.:

F1425-5



Size:

5 mg



Molecular Weight:

413.47 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

>98% by HPLC and NMR



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving; avoid multiple freeze-thaw cycles after dissolving in DMSO.



PDF Data Sheet:

Download PDF datasheet



NCBI RefSeq:

N/A



Image(s):

No



Shipping Method:

Room temperature shipping



References:

1. Anderson D J,
et al
. (2015) Cancer Cell., 28, 653
2. Zhou H J,
et al
. J. Med. Chem (2015) J. Med. Chem., 58, 9480





Details

CB-5083 is a potent ATPase activity inhibitor of p97. p97 (also called VCP) is an AAA-ATPase that plays an important role in various cellular functions including ER-associated degradation. CB-5803 induces significant unfolded protein response and apoptosis of various cancer cells. P97 is orally active and currently in clinical trials for relapsed multiple myeloma.