商品编号


XSTP726PA-1



品牌


SBI



公司


System Biosciences（SBI）



公司分类


exosome engineering


商品信息

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Overview:
Putting exosomes to work: Target exosomes to immune cells

Use exosomes to deliver protein, RNA, DNA, or small molecule cargo to immune cells with XStamp-IL-2. The patented XStamp technology is an optimized, exosome surface display system that efficiently places protein sequences on exosomal surfaces. The XStamp-IL-2 Lentivector fuses IL-2 sequences to the XStamp tag, ensuring that exosomes display IL-2 on their outer surface. Exosomes made from cells transfected or transduced with the XStamp-IL-2 Lentivector will now be targeted to cells expressing the IL-2 receptor, primarily immune cells.



Display IL-2 sequences on exosome surfaces

Target immune cells

Create stable XStamp-IL-2 cell lines



SBI
also offers a selection of pre-built targeting XStamp Lentivectors, as well as a clone-your-own XStamp Cloning and Expression Vector:




Cat.#

Specificity

Targeting Ligand Used





XSTP710PA-1

Clone-your-own

You decide



XSTP720PA-1

GI tract cells

Motilin



XSTP721PA-1

Neural cells

NCAM



XSTP722PA-1

Brain cells

BHP1



XSTP723PA-1

Cancer cells

GE11



XSTP724PA-1

Breast cancer cells

HER2



XSTP725PA-1

Antigen-presenting cells

CD40L/CD154



XSTP726PA-1

Immune cells

IL-2




How It Works:
Engineering exosomes with specific surface proteins


XStamp is based upon a C-terminal fusion of the C1C2 domain from the protein MFG-E8, which is targeted to the exosome surface. Protein sequences that are fused to the XStamp tag will efficiently display the protein ligand fusion on the surfaces of secreted exosomes.