商品编号


XSTP710PA-1



品牌


SBI



公司


System Biosciences（SBI）



公司分类


exosome engineering



商品信息

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Overview:
Putting exosomes to work: Target exosomes to specific tissues

Use exosomes to deliver protein, RNA, DNA, or small molecule cargo to specific tissues with XStamp. The patented XStamp technology is an optimized, exosome surface display system that efficiently places protein sequences on exosomal surfaces. When a tissue-specific protein ligand is used, the engineered exosomes become targeted to the specified tissue, enabling directed cargo delivery.



Display proteins on exosome surfaces

Coat exosomes with targeting ligands

Target specific cellular destinations

Create stable XStamp cell lines



In addition to the XStamp Cloning and Expression Lentivector,
SBI
also offers a selection of pre-built targeting XStamp Lentivectors:




Cat.#

Specificity

Targeting Ligand Used





XSTP710PA-1

Clone-your-own

You decide



XSTP720PA-1

GI tract cells

Motilin



XSTP721PA-1

Neural cells

NCAM



XSTP722PA-1

Brain cells

BHP1



XSTP723PA-1

Cancer cells

GE11



XSTP724PA-1

Breast cancer cells

HER2



XSTP725PA-1

Antigen-presenting cells

CD40L/CD154



XSTP726PA-1

Immune cells

IL-2




How It Works:
Engineering exosomes with specific surface proteins



XStamp is based upon a C-terminal fusion of the C1C2 domain from the protein MFG-E8, which is targeted to the exosome surface. Protein sequences that are fused to the XStamp tag will efficiently display the protein ligand fusion on the surfaces of secreted exosomes.

To target your protein ligand to the exosome surface, simply clone the gene encoding your protein ligand-of-interest into the MCS site of the XStamp Cloning and Expression Vector. Your ligand will have a 5’ secretion signal sequence and a C-term XStamp. The XStamp Lentivector also features a downstream EF1-Puromycin cassette for positive selection and, when packaged into virus, the XStamp Lentivector can be used to create stable cell lines that secrete your engineered exosomes.