商品编号


XSTP725PA-1



品牌


SBI



公司


System Biosciences（SBI）



公司分类


exosome engineering


商品信息

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Overview:
Putting exosomes to work: Target exosomes to antigen-presenting cells

Use exosomes to deliver protein, RNA, DNA, or small molecule cargo to antigen-presenting cells with XStamp-CD40L. The patented XStamp technology is an optimized, exosome surface display system that efficiently places protein sequences on exosomal surfaces. The XStamp-CD40L Lentivector fuses CD40L sequences to the XStamp tag, ensuring that exosomes display the CD40L on their outer surface. Exosomes made from cells transfected or transduced with the XStamp-CD40L Lentivector will now be targeted to cells expressing CD40, primarily antigen-presenting cells.



Display CD40L sequences on exosome surfaces

Target antigen-presenting cells

Create stable XStamp-CD40L cell lines



SBI
also offers a selection of pre-built targeting XStamp Lentivectors, as well as a clone-your-own XStamp Cloning and Expression Vector:




Cat.#

Specificity

Targeting Ligand Used





XSTP710PA-1

Clone-your-own

You decide



XSTP720PA-1

GI tract cells

Motilin



XSTP721PA-1

Neural cells

NCAM



XSTP722PA-1

Brain cells

BHP1



XSTP723PA-1

Cancer cells

GE11



XSTP724PA-1

Breast cancer cells

HER2



XSTP725PA-1

Antigen-presenting cells

CD40L/CD154



XSTP726PA-1

Immune cells

IL-2




How It Works:
Engineering exosomes with specific surface proteins


XStamp is based upon a C-terminal fusion of the C1C2 domain from the protein MFG-E8, which is targeted to the exosome surface. Protein sequences that are fused to the XStamp tag will efficiently display the protein ligand fusion on the surfaces of secreted exosomes.