商品编号


ax0322



品牌


Axolbio



公司


Axolbio



公司分类


Human Cells




1 Ea

商品信息

Description:
Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the V337M mutation (GTG>ATG) in the
MAPT
gene. This line is homozygous for the V337M mutation so both alleles contain the mutation. Click on the product images to see the data and further details.

The V337M mutation in MAPT has been implicated in frontotemporal dementia and may have a role in Alzheimer's disease. The mutation leads to accelerated aggregation of MAPT/tau protein into filament structures (Nacharaju
et al.
, 1999) and makes the MAPT/tau protein more suscept
IBL
e to hyperphosphorylation (Alonso
et al.
, 2004).

Click here to see more data on Axol Neural Stem Cells
Product Specification:


Starting material

Dermal fibroblast



Donor gender

Female



Donor age at sampling

64 yrs



Karyotype

Normal



Reprogramming method

Episomal vector



Induction method

Monolayer & chemically defined medium



Genetic modification

Homozygous for the MAPT V337M mutation (GTG>ATG)



Genetic modification

Contains a puromycin resistance cassette (intronic)



Size

≥1.5 million cells



Kit components

1 vial of Neural Stem Cells (≥1.5 million cells) and 1 bottle of Neural Plating-XF Medium (30 mL)



Growth properties

Adherent



Shipping conditions

Dry ice



Storage conditions

Liquid nitrogen