商品编号


ax0311



品牌


Axolbio



公司


Axolbio



公司分类


Human Cells




1 Ea

商品信息
axolGEM iPSC-Derived Neural Stem Cells LRRK2 G2019S HET (1.5 million cells) and Neural Plating-XF Medium (30 mL)
Description:
Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the
LRRK2
gene. This line is heterozygous for the G2019S mutation where one allele contains the mutation and the other allele is wild type at the locus. Click on the product images to see the data and further details.?


The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo
et al.
, 2006, Thaler
et al
., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West
et al
., 2005).?

Click here to see more data on Axol Neural Stem Cells
Product Specification:


Starting material

Dermal fibroblast



Donor gender

Female



Donor age at sampling

64 yrs



Karyotype

Normal



Reprogramming method

Episomal vector



Induction method

Monolayer & chemically defined medium



Genetic modification

Heterozygous for the LRRK2 G2019S mutation (GGC>AGC)



Genetic modification

Contains a puromycin resistance cassette (intronic)



Size

≥1.5 million cells



Kit components

1 vial of axolGEM Neural Stem Cells (≥1.5 million cells) and 1 bottle of Plating-XF Medium (30 mL)



Growth properties

Adherent



Shipping conditions

Dry ice



Storage conditions

Liquid nitrogen