商品编号


AG-40B-0034-C050



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

50 ?g


商品信息


More Information



Product Details



Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 12A; FGF-induc
IBL
e 14; Tweak-receptor; CD266; TNFRSF12A



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.



Crossreactivity

Human
Mouse



Specificity

Binds to mouse and human TWEAK.



MW

~35kDa (SDS-PAGE).



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.1eu>



Concentration

1mg/ml after reconstitution.



Reconstitution

Reconstitute with 50μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

UniProt link Q9NP84: FN14 (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly induc
IBL
e cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-κB) pathway. The TWEAK–Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.


Product References

No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells: J. Nys, et al.; PLoS One
8,
e61350 (2013)