商品编号


YIF-LF-P0270



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

10 ?g

商品信息


More Information



Product Details



Synonyms

CSF3; G-CSF; C17orf33; Filgrastim; Lenograstim; Pluripoietin; Granulocyte Colony-stimulating Factor



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



BIOLOG
ical Activity

The ED50 of G-CSF is typically 5-40 pg/ml. Measured in a cell proliferation assay using a murine myeloblastic cell line, NFS-60.



Purity

≥95% (SDS-PAGE)



Concentration

0.5 mg/ml



Formulation

Liquid in PBS, 10% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Avoid freeze/thaw cycles.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that promotes the proliferation and differentiation of cells in the granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-α and IFN-γ. Other cells can also secrete G-CSF after IL-1β,TNF-α and LPS activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. G-CSF has a effect in the treatment of leukopenia, AIDS, MDS and bone marrow transplantation. In humans, two distinct
CDN
A clones for G-CSF, encoding 207 and 204 amino acid precursor proteins, have been isolated. Both protein have identical amino acid sequences except for a three amino acid insertion (deletion) at the 35th amino acid residue from the N-terminus of the mature protein.


Product References
1) Fallah MJ et al., (2003) IJMS 28(3):131-134. (General)
2) Panopoulos AD and Watowich SS, (2008) Cytokine 42:277-288. (General)
3) Hirbe AC et al., (2007) Blood 109(8):3424-3431. (General)