商品编号


AG-40T-0017-C002



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

2 ?g


商品信息


More Information



Product Details



Synonyms

GCN5L2; Histone Acetyltransferase GCN5; Histone Acetyltransferase KAT2A; Lysine Acetyltransferase 2A; STAF97



Product Type

Protein



Properties



Source/Host

Sf21 cells



Sequence

Human GCN5 is fused to a His-tag.



Crossreactivity

Human



BIOLOG
ical Activity

~200-300ng are required for standard HAT assay.



Purity

≥95% (SDS-PAGE)



Concentration

Lot dependent (0.2-0.5mg/ml)



Formulation

Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.



Other Product Data

UniProt ID Q92830: GCN5 (human)



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

After opening, prepare aliquots and store at -80°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -80°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. It has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. It regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. GCN5 is a component of the Ada Two-A containing (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4.


Product References

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65: C. Buerki, et al.; Nucleic Acids Res.
36,
1665 (2008)