商品编号


AG-40A-0024T-C010



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Glucocorticoid-induced TNF Receptor Ligand; AITRL; Activation-induc
IBL
e TNF-related Ligand; TNFSF18



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular domain of human GITRL (aa 74-199) is fused at the C-terminus to a His-tag.



Crossreactivity

Human



MW

~17kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.06eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.06eu>



Concentration

After reconstitution:
for 10?g size:
0.1mg/ml
for 50?g size:
1 mg/ml



Reconstitution


10?g size:
Reconstitute with 100?l sterile water.
50?g size:
Reconstitute with 50?l sterile water.



Accession Number

AAH69319.1



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

NCBI link AAH69319.1: GITRL (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.