商品编号


YIF-LF-P0003



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

0.1 mg

商品信息


More Information



Product Details



Synonyms

GRX; GLRX; TTase-1; Glutaredoxin-1; Thioltransferase-1



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



BIOLOG
ical Activity

130U/mg (One unit will cause the oxidation of 1 μmole of NADPH per min)



Purity

≥95% (SDS-PAGE)



Concentration

1 mg/ml



Formulation

Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Avoid freeze/thaw cycles.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH (1). First discovered in E.coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase via two redox-active cysteine residues (2). The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12-kD dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress (3).


Product References
1) Holmgren, A. (1990) p. 146-154, CRC Press Inc., Boca Raton, FL. (General)
2) Holmgren, A. (1989) J. Biol. Chem. 264, 13963-13966. (General)
3) Jung, C. H. and Thomas, J. A. (1996) Arch. Biochem. Biophys. 335, 61-72. (General)
4) Alexios, V. et al. (1997) J. Biol. Chem. 272, 11236-11243. (General)