商品编号


AG-44B-0006-KI01



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

1 Set



商品信息


More Information



Product Details



Synonyms

Indoleamine 2,3-dioxygenase; INDO; IDO



Product Type

Set



Properties



Application Set

Compound Screening



Crossreactivity

Human



Kit Contains

1 Set
1x50?g of IDO1 (human) (rec.) (His) (highly active) (Prod. No. AG-40B-0161)
1x100?g of MMG-0358 (Prod. No. AG-CR1-3630)
Download our online Assay Procedure/Protocol.



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



Manual

No



Assay Procedure


Download PDF



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





IDO1 is a heme-containing enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, that plays a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity.
The IDO1 (human) Enzyme+Inhibitor Set contains the active enzyme IDO1 (human) (rec.) (His) (AG-40B-0161), compound MMG-0358 (AG-CR1-3630), a very potent and specific inhibitor of IDO1, and protocols that can be used for IDO1 enzyme activity and IDO1 inhibition experiments.
Both components can be used
in vitro
:
? ?For cell culture to study the effect of hIDO1 in a cellular system.
? ?For screening assay to search for new inhibitors of hIDO1.