商品编号


AG-40T-0122-C100



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

100 ?g


商品信息


More Information



Product Details



Synonyms

Inhibitor of Nuclear Factor κB Kinase Subunit β; IKK-B; IKK2



Product Type

Protein



Properties



Source/Host

Sf9 cells



Sequence

Recombinant human IKK-β (aa 1-700) is fused at the N-terminus to a His-tag.



Crossreactivity

Human



MW

~80kDa (SDS-PAGE)



Purity

≥85% (SDS-PAGE)



Concentration

1mg/ml



Formulation

Liquid. In 20mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50% glycerol.



Other Product Data

UniProt ID O14920: IKK-β (human)



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

After opening, prepare aliquots and store at -80°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -80°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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IKK-β is a serine kinase that plays an essential role in the NF-κB signaling pathway, which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. It acts as part of the canonical IKK complex in the conventional pathway of NF-κB activation. It phosphorylates inhibitors of NF-κB and these modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. Subsequently, NF-κB is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. IKK-β phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-κB subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. It phosphorylates also other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, it acts as an adapter protein for NFKBIA degradation in UV-induced NF-κB activation.