商品编号


CHI-MF-12022-C050



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

50 ?g

商品信息


More Information



Product Details



Synonyms

Interleukin-22; IL-10-related T Cell-derived-induc
IBL
e Factor



Product Type

Protein



Properties



Source/Host

CHO cells



Sequence

The extracellular domain of mouse IL-22 (aa 34-179) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.



Crossreactivity

Mouse



BIOLOG
ical Activity

Measured using CTLL-s indicator cells. Specific Activity: 1-1.5 x10
6
Units/mg.



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<0.1eu mu;g="" protein="" (lal="" test;="" lonza).="">0.1eu>



Reconstitution

Reconstitute 25?g vial in 250?l sterile water.
Reconstitute 50?g vial in 50?l sterile water.
Add 1X PBS to the desired protein concentration.



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
NCBI reference NP_058667.1: IL-22 (mouse)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Interleukin-22 (IL-22), also known as IL-10 related T cell derived induc
IBL
e factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (CRF29) and IL-10Rβ (CRF24), belonging to the class II cytokine receptor family.