商品编号


AG-40B-0097-C010



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Interleukin-36 Receptor Antago
NIST
Protein; IL-1F5; Interleukin-1 Family Member 5; IL-1δ; Interleukin-1δ Interleukin-1 Homolog 3; Interleukin-1-like Protein 1



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human IL36Ra (aa Val2-Asp155) is untagged.



Crossreactivity

Human



Application

Inhibition of
BIOLOG
ical activity of IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9).



MW

~17kDa



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.05eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.05eu>



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

Uni-Prot link Q9UBH0: Interleukin-36 receptor antago
NIST
protein




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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IL-36Ra/IL-1F5 is a highly and a specific antago
NIST
of the IL-1 receptor-related protein 2-mediated response to IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins le
ADI
ng to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, le
ADI
ng to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.