商品编号


AG-40B-0101-C010



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Interleukin-38; Interleukin-1 Family Member 10; IL-1F10



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Mouse IL-38 [IL-1F10] (aa 3-152) is fused at the C-terminus to a FLAG
?
-tag.



Crossreactivity

Mouse



MW

~20kDa



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized. Contains PBS + 0.5% Trehalose.



Other Product Data

Uni-Prot link
Q8R459
: Interleukin-38



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36α, IL-36β or IL-36γ) is important to increase their
BIOLOG
ical activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 le
ADI
ng to inflammation attenuation.


Product References

In vivo anti-inflammatory activities of novel cytokine IL-38 in Murphy Roths Large (MRL)/lpr mice: M. Chu, et al.; Immuno
BIOLOG
y
222,
483 (2017)

The effect of interleukin 38 on angiogenesis in a model of oxygen-induced retinopathy: J. Zhang, et al.; Sci. Rep.
7,
2756 (2017)

The enigmatic role of IL-38 in inflammatory diseases: T. Garraud, et al.; Cytokine Growth Factor Rev. ahead of print (2018)