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Adipogen/Jagged-1 (mouse):Fc (human) (rec.)/AG-40A-0157T-C010/10 ?g

重组蛋白
Adipogen/Jagged-1 (mouse):Fc (human) (rec.)/AG-40A-0157T-C010/10 ?g


商品编号


AG-40A-0157T-C010



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Protein Jagged-1; CD339; JAG1



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

Signal peptide and extracellular domain of mouse Jagged-1 (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG.



Crossreactivity

Mouse



BIOLOG
ical Activity

Inhibits
ADI
pogen
esis of 3T3L-1 cells.



MW

~150kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

For 10μg size: 0.1 mg /ml after reconstitution.
For 50μg size: 1mg/ml after reconstitution.



Reconstitution

For 10μg size: reconstitute with 100μl sterile water.
For 50μg size: reconstitute with 50μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

UniProt link Q9QXX0:
JAG1 (mouse)




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).


Product References

Notch ligands regulate the muscle stem-like state
ex vivo
but are not sufficient for retaining regenerative capacity: H. Sakai, et al.; PLoS ONE
12,
e0177516 (2017)


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产品货号:2028.0

2028.0 ¥
11至15个工作日送达