Adipogen/Jagged-1 (mouse):Fc (human) (rec.)/AG-40A-0157T-C010/10 ?g
重组蛋白
商品编号
AG-40A-0157T-C010
品牌
Adipogen
公司
Adipogen
公司分类
Proteins
Size
10 ?g
商品信息
More Information
Product Details
Synonyms
Protein Jagged-1; CD339; JAG1
Product Type
Protein
Properties
Source/Host
HEK 293 cells
Sequence
Signal peptide and extracellular domain of mouse Jagged-1 (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG.
Crossreactivity
Mouse
BIOLOG
ical Activity
Inhibits
ADI
pogen
esis of 3T3L-1 cells.
MW
~150kDa (SDS-PAGE)
Purity
≥90% (SDS-PAGE)
Endotoxin Content
<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>
Concentration
For 10μg size: 0.1 mg /ml after reconstitution.
For 50μg size: 1mg/ml after reconstitution.
Reconstitution
For 10μg size: reconstitute with 100μl sterile water.
For 50μg size: reconstitute with 50μl sterile water.
Formulation
Lyophilized. Contains PBS.
Other Product Data
UniProt link Q9QXX0:
JAG1 (mouse)
Shipping and Handling
Shipping
BLUE ICE
Short Term Storage
+4°C
Long Term Storage
-20°C
Handling Advice
After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/St
ABI
lity
Stable for at least 6 months after receipt when stored at -20°C.
Documents
MSD
S
Download PDF
Product Specification Sheet
Datasheet
Download PDF
Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).
Product References
Notch ligands regulate the muscle stem-like state
ex vivo
but are not sufficient for retaining regenerative capacity: H. Sakai, et al.; PLoS ONE
12,
e0177516 (2017)
产品货号:2028.0