商品编号


YIF-LF-P0022



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

0.1 mg

商品信息


More Information



Product Details



Synonyms

PMSR; MSRA; EC=1.8.4.11; Peptide Met(O) Reductase; Protein-Methionine-S-Oxide Reductase; Peptide-Methionine (S)-S-Oxide Reductase, Mitochondrial Peptide Methionine Sulfoxide Reductase



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



Purity

≥95% (SDS-PAGE)



Concentration

1 mg/ml



Formulation

Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Avoid freeze/thaw cycles.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Methione sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system, MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin (1), HIV protease (2) and a1-proteinase-inhibitor (3). Recent studies indicate that there is a connection between MsrA and Alzheimer's disease in mammals (4).


Product References
1) Sun, H. et al. (1999) Biochemistry. 38, 105-112. (General)
2) Davis, D. A. et al. (2000) Biochem. J. 346, 305-311. (General)
3) Abrams, W. R. et al. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 7483-7486. (General)
4) Gabbita, S. P. et al. (1999) J. Neu
Roche
m. 73, 1660-1666. (General)
5) Moskovitz, J. et al. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2095-2099. (General)