商品编号


AG-40T-0305-C050



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

50 ?g

商品信息


More Information



Product Details



Synonyms

Ubiquitin Thioesterase OTU1; DUBA-8; HIV-1-induced Protease 7; HIN-7; OTU Domain-containing Protein 2; OTUD2



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human OTU1 (Accession Nr. Q5VVQ6).



Crossreactivity

Human



Formulation

Liquid. In 50mM HEPES pH 7.5, 100mM NaCl, 10% Glycerol (v/v), 1mM TCEP.



Other Product Data


Use:
Ubiquitin?specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 0.1-1?M.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





OTU1 (Ubiquitin thioesterase OTU1, also known as YOD1) is a deubiquitinating enzyme of the ovarian tumor (otubain, also known as “Otu”) family. It is part of a multi-protein complex containing p97, suggesting this deubiquitinase may function in the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. A poss
IBL
e role for OTU1 is the trimming of polyubiquitin chains from substrates to facilitate their thre
ADI
ng through the VCP/p97 pore. OTU1 is capable of hydrolyzing K6-, K11-, K27- , K29-, and K33-linked polyubiquitin chains.