商品编号


AG-40T-0022-C002



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

2 ?g


商品信息


More Information



Product Details



Synonyms

Poly(ADP-ribose) Glycohydrolase



Product Type

Protein



Properties



Source/Host

Sf21 cells



Sequence

Human PARG is fused to a His-tag.



Crossreactivity

Human



BIOLOG
ical Activity

~100ng is required for poly(ADP-ribose) degradation assays.



Purity

≥95% (SDS-PAGE)



Concentration

Lot dependent (0.1-1.5mg/ml)



Formulation

Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.



Other Product Data

UniProt ID Q86W56:?PARG (human)




Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

After opening, prepare aliquots and store at -80°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -80°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.


Product References

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases: F. Rosenthal, et al.; Nat. Struct. Mol. Biol.
20,
502 (2013)