商品编号


YIF-LF-P0141



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

0.2 mg

商品信息


More Information



Product Details



Synonyms

RAC1; MIG5; TC25; p21-Rac1; Ras-like Protein TC25; Cell Migration-inducing Gene 5 Protein; Ras-related C3 Botulinum Toxin Substrate 1



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



Purity

≥95% (SDS-PAGE)



Formulation

Lyophilized from 50mM HEPES, pH8.0 / 10mM GSH.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

After reconstitution, store at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Rho-family GTPases, including Cdc42, Rac1 and RhoA, regulate actin
Cytoskeleton
and cell adhesion and play a central role in establishing cell polarisation. They also play an important role in cell growth and differentiation as well as transcriptional regulation. Migrating vertebrate cells in tissue culture display a characteristic polarization of the actin
Cytoskeleton
. The dynamic organization of the actin
Cytoskeleton
provides the force for cell motility and is regulated by small GTPases of the Rho family, in particular Rac1, RhoA and Cdc42. Rac1 (Ras-related C3 botulinum toxin substrate 1) is a small (~21 kDa) GTPase, and is a member of the Rac subfamily of the family Rho family of GTPases. Rac can be activated by extracellular signals through various types of membrane receptors including receptor tyrosine kinases such as the PDGF receptor. Rac executes its
BIOLOG
ical functions through activating downstream effectors, such as PAK (p21-activated kinase). Rac plays critical roles in a wide variety of cell functions including cell cycle control, regulation of gene expression, activation of NADPH oxidase of phagocytic cells, actin cytoskeletal reorganization, axonal guidance and cell migration.