商品编号


YIF-LF-P0039



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

0.5 mg

商品信息


More Information



Product Details



Synonyms

S100B; Protein S100-B; S-100 Protein β Chain; S-100 Protein Subunit β; S100 Calcium-binding Protein B



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



Purity

≥90% (SDS-PAGE)



Concentration

1 mg/ml



Formulation

Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Avoid freeze/thaw cycles.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





S100 protein family consists of highly homologous Ca2+ binding proteins that possess two EF-hand motifs. Most S100 proteins exist as dimers (frequently homodimers) within cells. Exclusively expressed in vertebrates, S100 is implicated in various intracellular and extracellular regulatory activities. Studies indicate that S100 proteins are involved in the inhibition of protein phosphorylation, inhibition of cytoskeletal constituent assembly, regulation of Ca2+ homeostasis, stimulation of enzyme activities, and interaction with transcription factors. S100B is abundant in the nervous system where it is predominantly expressed in astrocytes, oligodendrocytes and Schwann cells. When secreted by astrocytes, S100B has neurotrophic effects during development and nerve regeneration at physiologic (nanomolar) concentrations. High (micromolar) concentration of S100B, however, has shown to be neurotoxic, participating in the physiology of neurodegenerative disorders.


Product References
1) Michetti, F. and Gazzolo, D. (2002) Clinical Chemistry 48:12 2097-2104. (General)
2) Donato, R. (2001) Int J Biochem Cell Biol. 33, 637-668. (General)