商品编号


CHI-MF-110TNFR1-C050



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

50 ?g

商品信息


More Information



Product Details



Synonyms

Tumor Necrosis Factor Receptor 1; Tumor Necrosis Factor Receptor Superfamily Member 1a; TNFRSF 1A; CD120a



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular domain of mouse TNF-R1 (aa 30-212) is fused to the N-terminus of the Fc region of mouse IgG2a.



Crossreactivity

Mouse



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.06eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.06eu>



Reconstitution

Reconstitute with sterile water to a concentration of 100μg/ml.
Add 1X PBS to the desired protein concentration.



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

NCBI reference NP_035739.2: TNF-R1 (mouse)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





TNF receptor 1 [TNF-R1; CD120a] is a 55kDa type I transmembrane protein member of the TNF receptor superfamily and it is a receptor for TNF-α and homotrimeric lymphotoxin-α. It is essential for proper development of lymph node germinal centers and Peyer’s patches and for combating intracellular pathogens. Through the building of complexes this receptor can activate the transcription factor NF-κB, mediate apoptosis and function as a regulator of inflammation. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adapter proteins TRADD and TRAF2 have been shown to interact with this receptor and thus play regulatory roles in the signal transduction mediated by the receptor. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.TNF-R1 is stored in the Golgi and translocates to the cell surface following pro-inflammatory stimuli. TNF-α st
ABI
lizes TNF-R1 and induces its sequestering in lipid rafts, where it activates NF-κB and is cleaved by ADAM-17/TACE. Release of the cleaved TNF-R1 ECD helps to resolve inflammatory reactions, since it down-regulates cell surface TNF-R1 and provides soluble TNF-R1 to bind TNF-α. Mutations in humans have been shown to be associated with the tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome and with several neurological pathologies.