商品编号


YIF-LF-P0079



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

20 ?g

商品信息


More Information



Product Details



Synonyms

TNF; TNFA; TNF-α



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



BIOLOG
ical Activity

The ED50 as determined by the cytolysis of murine L929 cells in the presense of actinomycin D is 0.03-0.06 ng/ml.



Purity

≥98% (SDS-PAGE)



Formulation

Liquid in 20mM Tris, pH 8.0, 1mM EDTA, 10% Glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

After reconstitution, store at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Tumor necrosis factor-α (TNF-α) is a pleiotropic pro-inflammatory cytokine produced mainly by activated macrophages and in smaller amounts by several other types of cell. TNF-α has been isolated and characterized from a large number of mammals and fish species. TNF-α is expressed in two different forms: a soluble. Mature 17kDa form and a transmembrane 26kDa form. TNF-α interacts with two distinct cell-surface receptors, Tumor necrosis factor receptor 1 (TNFR1) and TNFR2. these mediate the cellular actions. The actions of TNF-α are diverse and profound involving inflammation, apoptosis, cell proliferation and the stimulation of various aspects within the immune system. TNF-α is increasingly recognized as a key regulator of lipid metabolism in
ADI
pose tissue and protein catabolism in muscle and in disease states such as cancer, Acquired Immune Deficiency Syndrome (AIDS) and obesity-related insulin resistance.


Product References
1) Wen-Xing Ding et al (2004) J.Cell. Mol. Med 8(4);445-454. (General)
2) Sudhir Gupta (2002) Journal of Clinical Immunology 22(4);185-194. (General)
3) Frederick W. goetz et al (2004) Developmental and comparative Immunology 28;487-497. (General)
4) Havell, E.A. (1987) J. Immunol. 39:4225-4231. (General)