商品编号


AG-40T-0558-C050



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

50 ?g

商品信息


More Information



Product Details



Synonyms

Ubiquitin C-terminal Hydrolase 11; Deubiquitinating Enzyme 11; Ubiquitin Thioesterase 11; Ubiquitin-specific-processing Protease 11; TGT



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human
USP
11 (Accession Nr. NP_004642.2).



Crossreactivity

Human



MW

~110kDa



Purity

≥85% (SDS-PAGE)



Formulation

Liquid. In 50mM HEPES, pH7.5, 100mM NaCl, 10% glycerol, 1mM TCEP.



Other Product Data


Use:
Reaction conditions will need to be optimized for each specific application. We recommend an initial recombinant human
USP
11 concentration of 10-50 nM when using Ubiquitin-AMC (AG-40T-0459) or Ubiquitin-Rh110 (AG-40T-0459RH) substrates.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Ubiquitin carboxyl-terminal hydrolase 11 (
USP
11) is a specialized cysteine protease with a predicted molecular weight of 110 kDa.
USP
11 is a member of the peptidase C19 family and the human protein shares 77% amino acid sequence identity with its mouse ortholog.
USP
11 plays a role in DNA double-strand break (DSB) repair, and cells are hypersensitive to γ r
ADI
ation when
USP
11 has been knocked down.
USP
11 overexpression is often observed in colorectal cancer and melanoma and is correlated with poor survival. In these cases
USP
11 may be driving disease states by st
ABI
lizing cIAP2. Interestingly, recent genetic analysis suggests that
USP
11 was generated during the course of vertebrate evolution by a small-scale duplication of the
USP
4-encoding region. This recombinant protein contains a C-terminal 6-His tag.