商品编号


YIF-LF-P0388



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

0.5 mg

商品信息


More Information



Product Details



Synonyms

VIM; Vimentin



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



Purity

≥95% (SDS-PAGE)



Formulation

Lyophilized from 20mM Tris 10mM NaCl, pH8.0.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

After reconstitution, store at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Vimentin is a member of the intermediate filament family of proteins found in various non-epithelial cells, especially mesenchymal cells. Vimentin is respons
IBL
e for maintaining cell shape, integrity of the cytoplasm, and st
ABI
lizing cytoskeletal interactions. Vimentin plays a significant role in supporting and anchoring the position of the organelles in the cytosol. Although most intermediate filaments are stable structures, vimentin also has a dynamic nature which is important when offering flexibility to the cell. Two monomers which have central α-helical domains, capped on each end by non-helical domains twist around each other to form a coiled-coil dimer. Two dimers then form a tetramer, which, in turn, form a sheet by interacting with other tetramers. There are some reports related to the biochemical function of intermediate filament network. The intracellular movement of LDL-derived cholesterol from the lysosome to the site of esterification is a vimentin-dependent process. A role for vimentin in mechanotransduction of shear stress has also been suggested. The mechanical stress of fluid shear on endothelial cells seems to trigger MAPK signaling pathways and stimulates proliferation.


Product References
1) Pekny M and Lane EB, (2007) Exp Cell Res 313(10):2244-2254. (General)
2) Holwell TA et al., (1999) J Lipid Res 40(8):1440-1452. (General)
3) Henrion D et al., (1997) J Clin Invest 100:2909-2914. (General)
4) Sarria AJ et al., (1992) J Biol Chem 267(27):19455-19463. (General)