商品编号


AG-40B-0146-C010



品牌


Adipogen



公司


Adipogen



公司分类


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Zn-α-2-GP; Zn-α-2-Glycoprotein; ZAG; ZA2G; AZGP1; ZNGP1



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human full-length zinc-α-2-glycoprotein (aa 21-298) is untagged.



Crossreactivity

Human



MW

~30kDa



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.1eu>



Concentration

10μg size: 0.1mg/ml after reconstitution.
50μg size: 1mg/ml after reconstitution.




Reconstitution

10μg size: Reconstitute with 100μl sterile water.
50μg size: Reconstitute with 50μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

Uni-Prot link P25311: Zinc-α-2-glycoprotein (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Zinc-α-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in
in vitro
and
in vivo
experiments. Due to its expression in, and secretion from
ADI
pocytes, ZAG is considered an
ADI
pokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in
ADI
pocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin induc
IBL
e protein rather than β
2
-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its α1 and α2 domain helices.


Product References

Strong and weak zinc binding sites in human zinc-α2-glycoprotein: A.A. Kumar, et al.; FEBS Lett.
587,
3949 (2013)