商品编号


A3600



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Proteasomes / Activators / Subunits



Size

25 ?g

商品信息

Adrm1 is an integral Ub receptor of the 26S proteasome. Adrm1 binds both Ub and polyUb chains via its N-terminal Pru domain. The Pru domain also binds S1 to locate Adrm1 on the 26S proteasome. The C-terminal domain of Adrm1 binds and activates the deubiquitinating enzyme Uch37, though which Uch37 is recruited to the 26S proteasome. Currently, it is not known whether Adrm1 activates Uch37 to deubiquitinate polyUb chains.

Additional Information






Product Name:

Adrm1/Uch37



Also Known As:

Adrm1 (ADRM1;ARM1; GP110; Rpn13 ); Uch37 (UCHL5;UCH37; CGI-70; INO80R; UCH-L5 )



Catalog No.:

A3600



Size:

25 ?g



Molecular Weight:

Adrm1 (42,2 kDa), Uch37 (37.6 kDa)



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~95% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_007002 (Adrm1), NM_015984 (Uch37)



Image(s):

N/A



Shipping Method:

Dry ice shipping



References:

1. Verma R,
et al
. (2000) Mol Biol Cell 11(10), 3425 – 3439.
2. Koulich E,
et al
. (2007) Mol Biol Cell, 19(3) 1072 – 1082. 3. Husnjak K,
et al
. (2008) Nature 453, 481 – 488.
4. Lee BH,
et al
. (2010) Nature 467, 179 – 184.




Details

Adrm1 is an integral Ub receptor of the 26S proteasome. Adrm1 binds both Ub and polyUb chains via its N-terminal Pru domain. The Pru domain also binds S1 to locate Adrm1 on the 26S proteasome. The C-terminal domain of Adrm1 binds and activates the deubiquitinating enzyme Uch37, though which Uch37 is recruited to the 26S proteasome. Currently, it is not known whether Adrm1 activates Uch37 to deubiquitinate polyUb chains.