商品编号


C1101



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E2 Conjugating Enzymes



Size

100 ?g


商品信息

Ube2A is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It shares 95% amino acid sequence identity with Ube2B. One function of Ube2A involves the formation of Ube2A/Rad18 (an E3 enzyme) complex to monoubiquitinate proliferating cell nuclear antigen (PCNA) thus activating it to repair DNA damage. Ube2A is an X – chromosomal gene. Mutations in Ube2A have been linked to intellectual dis
ABI
lity (ID), severely impaired speech, amongst other symptoms.

Additional Information






Product Name:

6xHis-Ube2A (Rad6A)



Also Known As:

UBC2; HHR6A; MRXSN; RAD6A; MRXS30



Catalog No.:

C1101



Size:

100 ?g



Molecular Weight:

17.1 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~95% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_003336



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2A (Rad6A)







Shipping Method:

Dry ice shipping



References:

1. Jentsch S,
et al
. (1987) Nature 329(6135), 131 – 134.
2. Koken MH,
et al
.(1991) Proc Natl Acad Sci USA 88(20), 8865 – 8869. 3. de Leeuw N,
et al
. (2010) Am J Med Genet A 152A(12), 3084 – 3090.
4. Hibbert RG,
et al
. (2011) Proc Natl Acad Sci USA 108, 5590–5595.




Details

Ube2A is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It shares 95% amino acid sequence identity with Ube2B. One function of Ube2A involves the formation of Ube2A/Rad18 (an E3 enzyme) complex to monoubiquitinate proliferating cell nuclear antigen (PCNA) thus activating it to repair DNA damage. Ube2A is an X – chromosomal gene. Mutations in Ube2A have been linked to intellectual dis
ABI
lity (ID), severely impaired speech, amongst other symptoms.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2A (Rad6A)