商品编号


C1301



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E2 Conjugating Enzymes



Size

100 ?g


商品信息

UbcH10 (Ubc2C) is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It plays a major role in the mitosis in cell cycle by binding to the anaphase-promoting complex/cyclosome (APC/C), which causes autoubiquitination and degradation of UbcH10. This in turn st
ABI
lizes cyclin A, promoting cells enter into S phase. UbcH10 also promotes ubiquitination of many substrates of APC/C.

Additional Information






Product Name:

6xHis-Ube2C (UbcH10 )



Also Known As:

UBCH10; dJ447F3.2



Catalog No.:

C1301



Size:

100 ?g



Molecular Weight:

19.7 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~95% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_007019



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2C (UbcH10 )







Shipping Method:

Dry ice shipping



References:

1. Hershko A,
et al
. (1994) J Biol CHem 269, 4940 – 4946.
2. Aristarkhov A,
et al
. (1996) Proc Natl Acad Sci USA 93(9), 4294 – 4299. 3. Rape M,
et al
. (2006) Cell. 124(1), 89 – 103.
4. Berlingieri MT,
et al
. (2007) Oncogene 26, 2136 – 2140.




Details

UbcH10 (Ubc2C) is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It plays a major role in the mitosis in cell cycle by binding to the anaphase-promoting complex/cyclosome (APC/C), which causes autoubiquitination and degradation of UbcH10. This in turn st
ABI
lizes cyclin A, promoting cells enter into S phase. UbcH10 also promotes ubiquitination of many substrates of APC/C.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2C (UbcH10 )