商品编号


C2301



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E2 Conjugating Enzymes



Size

100 ?g


商品信息

Ube2G2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It has been shown to complex with the E3 ligase called GP78 to catalyze K48 – linked Ub chains. This is an endoplasmic reticulum (ER) associated system to help degrade misfolded ER proteins. Ube2G2 likely interacts with Parkin (an E3 ligase that causes autosomal recessive juvenile Parkinsonism) to ubiquitinate and degrade insoluble Pael receptors.

Additional Information






Product Name:

6xHis-Ube2G2



Also Known As:

UBC7



Catalog No.:

C2301



Size:

100 ?g



Molecular Weight:

18.6 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~95% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_003343



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2G2







Shipping Method:

Dry ice shipping



References:

1. Katsanis N,
et al
. (1998) Genomics 51(1), 128 – 131.
2. Imai Y,
et al
. (2001) Cell 105(7), 891 – 902.
3. Arai R,
et al
. (2006) Acta Crystallogr Sect F Struct Biol Chryst Commun 62(Pt 4), 330 – 334.
4. Li W,
et al
. (2007) Nature 446, 333-7.




Details

Ube2G2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade respons
IBL
e for ubiquitination of protein substrates. It has been shown to complex with the E3 ligase called GP78 to catalyze K48 – linked Ub chains. This is an endoplasmic reticulum (ER) associated system to help degrade misfolded ER proteins. Ube2G2 likely interacts with Parkin (an E3 ligase that causes autosomal recessive juvenile Parkinsonism) to ubiquitinate and degrade insoluble Pael receptors.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified 6xHis-Ube2G2