商品编号


H1610



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

50 ?g


商品信息

Ataxin3 is a Machado-Josephine domain-containing deubiquitinating enzyme. Machado–Joseph disease (MJD) is a neurodegenerative disorder caused by polyQ expansion in ataxin-3. Ataxin3 is involved in protein homeostasis maintenance, transcription,
Cytoskeleton
regulation, myogenesis and degradation of misfolded chaperone substrates.

Additional Information






Product Name:

GST-Ataxin3(Q22)



Also Known As:

ATXN3; AT3; JOS; MJD; ATX3; MJD1; SCA3



Catalog No.:

H1610



Size:

50 ?g



Molecular Weight:

41.2 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~ 90% by SDS-PAGE



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_004993.5



Image(s):

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified GST-Ataxin3(Q22)







Shipping Method:

Dry ice shipping



References:

1. Tzvetkov N,
et al
. (2007) Biol. Chem. 388:973-978
2. Li F,
et al
. (2002) J. Biol. Chem. 277:45004-45012
3. Winborn BJ,
et al
. (2008) J Biol Chem. 26;283(39):26436-43




Details

Ataxin3 is a Machado-Josephine domain-containing deubiquitinating enzyme. Machado–Joseph disease (MJD) is a neurodegenerative disorder caused by polyQ expansion in ataxin-3. Ataxin3 is involved in protein homeostasis maintenance, transcription,
Cytoskeleton
regulation, myogenesis and degradation of misfolded chaperone substrates.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified GST-Ataxin3(Q22)