商品编号


H3101



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

100 ?g

商品信息

Deubiquitinating enzymes (DUBs) are proteases that posses the
ABI
lity to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB2 is a member of the ovarian tumor domain family. Not much is known about the
BIOLOG
ical function of this enzyme, but it may deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.

Additional Information






Product Name:

OTUB2



Also Known As:

OTB2; OTU2; C14orf137



Catalog No.:

H3101



Size:

100 ?g



Molecular Weight:

27.2 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~95% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_023112



Image(s):

N/A



Shipping Method:

Dry ice shipping



References:

1. Balakirev MY,
et al.
(2003) EMBO Rep 4(5), 517 – 522.
2. Reyes-Turcu FE,
et al.
(2009) Annu Rev Biochem 78, 363 – 397. 3. Li S,
et al.
(2010) J Biol Chem 285(7), 4291 – 4297.




Details

Deubiquitinating enzymes (DUBs) are proteases that posses the
ABI
lity to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB2 is a member of the ovarian tumor domain family. Not much is known about the
BIOLOG
ical function of this enzyme, but it may deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.