商品编号


H3211



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

100 ?g

商品信息

Deubiquitinating enzymes (DUBs) are proteases that posses the
ABI
lity to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. A20 downregulates the NF-κB pathway and proinflammatory gene expression in cells such as macrophages. The N-terminal domain of A20 contains the DUB activity.

Additional Information






Product Name:

GST-A20
(1-365)



Also Known As:

TNFAIP3; OTUD7C; TNFA1P2



Catalog No.:

H3211



Size:

100 ?g



Molecular Weight:

89.6 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~95% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_006290



Image(s):

N/A



Shipping Method:

Dry ice shipping



References:

1. Opipari AW Jr,
et al.
(1990) J Biol Chem 265(25), 14705 – 14708.
2. Boone DL,
et al.
(2004) Nat Immunol 5(10), 1052 – 1060.




Details

Deubiquitinating enzymes (DUBs) are proteases that posses the
ABI
lity to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. A20 downregulates the NF-κB pathway and proinflammatory gene expression in cells such as macrophages. The N-terminal domain of A20 contains the DUB activity.