商品编号


H6500



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

50 ?g


商品信息

USP
15 belongs to a family of deubiquitinating enzymes called the DU subfamily. Within this subfamily are
USP
4 and
USP
11 because they all contain an N-terminal “domain present in ubiquitin specific proteases” (D
USP
) and ubiquitin-like (UBL) domains.
USP
15 has been shown to play a role in st
ABI
lizing and activating caspase-3 during Paclitaxel-induced apoptosis.
USP
15 also deubiquitinates IκBα which is an inhibitor of NF-κB.

Additional Information






Product Name:

GST-
USP
15



Also Known As:

UNPH4; UNPH-2



Catalog No.:

H6500



Size:

50 ?g



Molecular Weight:

112.4 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

>70% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_001252078



Image(s):

Images
(Click image to enlarge)

Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified GST-
USP
15



Shipping Method:

Dry ice shipping



References:

1. Reyes-Turcu FE,
et al
. (2009) Annu Rev Biochem 78, 363 – 397.
2. Xu M,
et al
. (2009) Biochem Biophys Res Commun 388, 366-371. 3. Harper S,
et al
. (2011) Biochemistry 50(37), 7995 – 8004.




Details


USP
15 belongs to a family of deubiquitinating enzymes called the DU subfamily. Within this subfamily are
USP
4 and
USP
11 because they all contain an N-terminal “domain present in ubiquitin specific proteases” (D
USP
) and ubiquitin-like (UBL) domains.
USP
15 has been shown to play a role in st
ABI
lizing and activating caspase-3 during Paclitaxel-induced apoptosis.
USP
15 also deubiquitinates IκBα which is an inhibitor of NF-κB.

Images
(Click image to enlarge)

Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified GST-
USP
15