商品编号


H7810



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Deubiquitinating Enzymes



Size

50 ?g


商品信息

USP
30(57-517) contains the catalytic domain of
USP
30 with the N-terminal membrane bound domain being deleted.
USP
30 deubiquitinates substrates of Parkin including MIRO1, TOMM20, MFN1, and MFN2 on mitochondrial membranes and functions to suppress mitophagy. It prefers cleavage of K6- and K11-linked polyubiquitin chains.

Additional Information






Product Name:

GST-
USP
30(57-517)



Also Known As:

N/A



Catalog No.:

H7810



Size:

50 ?g



Molecular Weight:

51.5 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~ 70% by SDS-PAGE



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_032663.4



Image(s):

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified OTUD6B







Shipping Method:

Dry ice shipping



References:

1. Bingol B,
et al
. (2014) Nature 510: 370
2. Cunningham CN,
et al
. (2015) Nat Cell Biol. 17: 160
3. Wang, Y,
et al
. (2015) Autophagy 11: 595




Details


USP
30(57-517) contains the catalytic domain of
USP
30 with the N-terminal membrane bound domain being deleted.
USP
30 deubiquitinates substrates of Parkin including MIRO1, TOMM20, MFN1, and MFN2 on mitochondrial membranes and functions to suppress mitophagy. It prefers cleavage of K6- and K11-linked polyubiquitin chains.

Images:
(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified OTUD6B