商品编号


F6181



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

25 mg

商品信息

CAL-101 (idelalisib or GS-1101) is a potent inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with IC50 of 2.5 nM in cell-free assays. CAL-101 decreases pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM.

Additional Information






Product Name:

CAL-101 (Idelalisib, GS-1101)



Also Known As:

(S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one



Catalog No.:

F6181



Size:

25 mg



CAS:

870281-82-6



Formula:

C
22
H
18
FN
7
O



Molecular Weight:

415.42 Da



Form:

Lyophilized powder



Quality Assurance:

>98% by HPLC and NMR



Source:

Synthetic



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving



PDF Data Sheet:

Download PDF datasheet



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

Lannutti BJ,
et al
. (2011) Blood, 117(2), 591-594.




Details

CAL-101 (idelalisib or GS-1101) is a potent inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with IC50 of 2.5 nM in cell-free assays. CAL-101 decreases pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM.

Solubility:

> 20 mg/ml in DMSO