商品编号


TG4170



品牌


TopoGEN



公司


TopoGEN



公司分类


Inhibitors and poisons



Size

0.25 ml

商品信息


Ellipticine Description
Ellipticine is a topoisomerase II poison that induces topo II dependent cleavages.?


Chemical Name:
5,11-Dimethyl-6H-Pyrido[4,3]Carbazole


Molecular Formula:
C17H14N2


Molecular Weight:
246.31


TopoGEN
provides this reagent as a control poison/inhibitor of topoisomerase II.? For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of assay being employed (SDSK+ vs. R
ADI
oactive End Labeled DNA vs. testing for plasmid cleavages).? Note that large amounts of enzyme will be required to detect cleavage complex, compared to assays that measure catalytic activity.


Vial Contents:
TG4170 is supplied already s
USP
ended in DMSO at 10 mM (0.25 ml) and is ready for use.? The drug is pre-tested and shown to induce topo cleavages using purified human topoisomerase from
TopoGEN
.
?