商品编号


TG4160



品牌


TopoGEN



公司


TopoGEN



公司分类


Inhibitors and poisons



Size

0.25 ml

商品信息

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Ge
NIST
ein Description
Ge
NIST
ein is an isoflavone and an inhibitor of tyrosine protein kinases.? It has been reported to induce topo II dependent cleavages (Biochem. Pharmacol. 39:737-740 [1990]).?
TopoGEN
provides this reagent as a control poison/inhibitor of topoisomerase II (Note, Ge
NIST
ein may also inhibit topoisomerase I.)? For in vitro cleavage detection, we recom- mend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of assay being employed (SDSK+ vs. R
ADI
oactive End Labeled DNA vs. testing for plasmid cleavages).? Note that large amounts of enzyme will be required to detect cleavage complex, compared to assays that measure catalytic activity.


Chemical Name:
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one


Molecular Formula:
C15H10O5


Molecular Weight:
270.23


Vial Contents
:
TG4160 is supplied already s
USP
ended in DMSO at 10 mM (0.25 ml) and is ready for use. The drug is pre-tested and shown to induce topo cleavages using purified human topoisomerase from
TopoGEN
.

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