商品编号


5681/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

50 mg

商品信息

Description:
Activator of SUMO-activating enzyme, E1 ligase

Chemical Name:
4-Methoxy-
N
-[5-(4-methoxyphenyl)-1,3,4-ox
ADI
azol-2-yl-2-benzothiazolamine

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes
in vitro
. Improves ventricular function in a mouse model of heart disease.



Technical Data



M. Wt

354.38



Formula

C
17
H
14
N
4
O
3
S



Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

862974-25-2



PubChem ID

3236395



InChI Key

FBCSWQRNKAYAGY-UHFFFAOYSA-N



Smiles

COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

7.09

20mM with gentle warming





Preparing Stock Solutions

The following data is based on the
product
molecular weight
354.38
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.82 mL

14.11 mL

28.22 mL



5 mM

0.56 mL

2.82 mL

5.64 mL



10 mM

0.28 mL

1.41 mL

2.82 mL



50 mM

0.06 mL

0.28 mL

0.56 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Kho

et al
(2015) Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat.Commun.
6
7229 PMID: 26068603




Keywords: N106, supplier, SUMO-activating, enzymes, E1, ligases, SERCA2a, SUMOylation, heart, diseases, activators, Other, Ligases, Other, Ligases,
Tocris
Bioscience