商品编号


5131/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

10 mg

商品信息

Description:
Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport

Chemical Name:

N
-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1
H
-benzimidazole-5-carboxamide

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Protects against
α
-synuclein toxicity. Reverses the
α
-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. Promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.



Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.



Compound Libraries

NAB 2 is also offered as part of the
Tocris
creen Plus. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

389.88



Formula

C
23
H
20
ClN
3
O



Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

1504588-00-4



PubChem ID

82017756



InChI Key

CZSLEMCYYGEGKP-UHFFFAOYSA-N



Smiles

O=C(NCC4=C(Cl)C=CC=C4)C1=CC=C2C(N=CN2C3=CC(C)=CC=C3C)=C1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

38.99

100



ethanol

38.99

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
389.88
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.56 mL

12.82 mL

25.65 mL



5 mM

0.51 mL

2.56 mL

5.13 mL



10 mM

0.26 mL

1.28 mL

2.56 mL



50 mM

0.05 mL

0.26 mL

0.51 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Tardiff

et al
(2013) Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates
α
-synuclein toxicity in neurons. Science
342
979 PMID: 24158909


Chung

et al
(2013) Identification and rescue of
α
-synuclein toxicity in Parkinson patient-derived neurons. Science
342
983 PMID: 24158904




Keywords: NAB 2, supplier, NAB2, α, alpha-synuclein, a-synuclein, toxicity, Parkinsons, disease, parkinson's, NEDD4, rsp5, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience